CRISPR interference to evaluate modifiers of C9ORF72-mediated toxicity in FTD

CRISPR interference to evaluate modifiers of C9ORF72-mediated toxicity in FTD

Treatments for neurodegenerative disease, including Frontotemporal dementia (FTD) and Amyotrophic lateral sclerosis (ALS), remain rather limited, underscoring the need for greater mechanistic insight and disease-relevant models. Our ability to develop novel disease models of genetic risk factors, di...

Full description

Bibliographic Details
Main Authors: Sarah Pickles, Desiree Zanetti Alepuz, Yuka Koike, Mei Yue, Jimei Tong, Pinghu Liu, Yugui Zhou, Karen Jansen-West, Lillian M. Daughrity, Yuping Song, Michael DeTure, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, Keith A. Josephs, Dennis W. Dickson, Michael E. Ward, Lijin Dong, Mercedes Prudencio, Casey N. Cook, Leonard Petrucelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
frontotemporal dementia
amyotrophic lateral sclerosis
STMN2
C9orf72
CRISPR interference
TDP-43
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1251551/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1251551/full

Similar Items