WIP1 phosphatase as a potential therapeutic target in neuroblastoma.

WIP1 phosphatase as a potential therapeutic target in neuroblastoma.

The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively regulates multiple proteins involved in DNA damage response including p53, CHK2, Histone H2AX, and ATM, and it has been shown to be overexpressed or amplified in human cancers including breast and ovaria...

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Bibliographic Details
Main Authors: Mark Richter, Tajhal Dayaram, Aidan G Gilmartin, Gopinath Ganji, Sandhya Kiran Pemmasani, Harjeet Van Der Key, Jason M Shohet, Lawrence A Donehower, Rakesh Kumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319922?pdf=render

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http://europepmc.org/articles/PMC4319922?pdf=render

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