Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

Abstract G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G4C2 insertion length is variable, and patients can carry up to several thousand repeats. Dipeptide r...

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Bibliographic Details
Main Authors: Javier Morón-Oset, Lilly Katharina Sophie Fischer, Nathalie Jauré, Pingze Zhang, Annika Julia Jahn, Tessa Supèr, André Pahl, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Acta Neuropathologica Communications
Subjects:
C9orf72
Glycine–alanine
Repeat length
Drosophila
Toxicity
Online Access:https://doi.org/10.1186/s40478-023-01634-6

Internet

https://doi.org/10.1186/s40478-023-01634-6

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