3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal hemoglobin (HPFH), has been found to ameliorate hemogl...

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Váldodahkkit: Pamela Himadewi, Xue Qing David Wang, Fan Feng, Haley Gore, Yushuai Liu, Lei Yu, Ryo Kurita, Yukio Nakamura, Gerd P Pfeifer, Jie Liu, Xiaotian Zhang
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: eLife Sciences Publications Ltd 2021-09-01
Ráidu:eLife
Fáttát:
epigenetics
3D genomics
hemoglobin switch
Liŋkkat:https://elifesciences.org/articles/70557

Interneahtta

https://elifesciences.org/articles/70557

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