IFNα and 5-Aza-2’-deoxycytidine combined with a dendritic-cell targeting DNA vaccine alter tumor immune cell infiltration in the B16F10 melanoma model

IFNα and 5-Aza-2’-deoxycytidine combined with a dendritic-cell targeting DNA vaccine alter tumor immune cell infiltration in the B16F10 melanoma model

IntroductionDNA vaccines containing a fusion of the gene encoding chemokine MIP-3α (CCL20), the ligand for CCR6 on immature dendritic cells (DCs), to melanoma-associated antigen genes have enhanced anti-tumor immunity and efficacy compared to those lacking the chemokine gene. Previous work has shown...

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Bibliographic Details
Main Authors: James T. Gordy, Avinaash K. Sandhu, Kaitlyn Fessler, Kun Luo, Aakanksha R. Kapoor, Samuel K. Ayeh, Yinan Hui, Courtney Schill, Fengyixin Chen, Tianyin Wang, Styliani Karanika, Joel C. Sunshine, Petros C. Karakousis, Richard B. Markham
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
interferon
5-Aza-2’-deoxycitidine
dendritic cell
vaccine
B16F10 melanoma
chemokine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1074644/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1074644/full

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