Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of SOD1G93A mice

Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of SOD1G93A mice

Stem cell therapy is considered a promising approach in the treatment of amyotrophic lateral sclerosis (ALS) and mesenchymal stem cells (MSCs) seem to be the most effective in ALS animal models. The umbilical cord (UC) is a source of highly proliferating fetal MSCs, more easily collectable than othe...

Full description

Bibliographic Details
Main Authors: Francesca Sironi, Antonio Vallarola, Martina Bruna Violatto, Laura Talamini, Mattia Freschi, Roberta De Gioia, Chiara Capelli, Azzurra Agostini, Davide Moscatelli, Massimo Tortarolo, Paolo Bigini, Martino Introna, Caterina Bendotti
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Stem Cell Research
Subjects:
Max 6
Amyotrophic lateral sclerosis
Mesenchymal stem cells
Umbilical cord
Transgenic SOD1G93A mice
Motor neuron
Gliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117302350

Internet

http://www.sciencedirect.com/science/article/pii/S1873506117302350

Similar Items