Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay

Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay

Human APOBEC3G (hA3G) is a cytidine deaminase which inhibits HIV-1 replication. The HIV-1 accessory protein viral infectivity factor (Vif) counteracts with hA3G by targeting it for proteasomal degradation. In this work, we constructed and optimized molecular models of the hA3G dimer and the hA3G–Vif...

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Bibliographic Details
Main Authors: Congjie Zhai, Ling Ma, Zhixin Zhang, Jiwei Ding, Jing Wang, Yongxin Zhang, Xiaoyu Li, Fei Guo, Liyan Yu, Jinming Zhou, Shan Cen
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
HIV
Vif
APOBEC3G
Motif
Modeling
hA3G–Vif complex
hA3G dimer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383517300199

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http://www.sciencedirect.com/science/article/pii/S2211383517300199

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