Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats

Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats

Abstract Suppressor of mek1 (Dictyostelium) homolog 2 (Smek2), was identified as one of the responsible genes for diet-induced hypercholesterolemia (DIHC) of exogenously hypercholesterolemic (ExHC) rats. A deletion mutation in Smek2 leads to DIHC via impaired glycolysis in the livers of ExHC rats. T...

Full description

Bibliographic Details
Main Authors: Yasutake Tanaka, Michio Kawano, Sawako Nakashima, Chisato Yamaguchi, Makoto Asahina, Mai Sakamoto, Bungo Shirouchi, Kousuke Tashiro, Katsumi Imaizumi, Masao Sato
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26115-z

Internet

https://doi.org/10.1038/s41598-022-26115-z

Similar Items