Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

Abstract Background Gambogic acid is a natural component isolated from gamboge that possesses anticancer properties. Our previous study suggested that gambogic acid might be involved in autophagy; however, its role in pancreatic cancer remained unclear. Methods Cell viability and apoptosis of pancre...

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Bibliographic Details
Main Authors: Hongcheng Wang, Zhi Zhao, Shizhou Lei, Shaoli Li, Zhen Xiang, Xiaoyu Wang, Xiuyan Huang, Guanggai Xia, Xinyu Huang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cancer Cell International
Subjects:
Pancreatic cancer
Autophagy
Gambogic acid
Reactive oxygen species
Chloroquine
Online Access:http://link.springer.com/article/10.1186/s12935-018-0705-x

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http://link.springer.com/article/10.1186/s12935-018-0705-x

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