Probing the multitargeting potential of n-hexane fraction of Gongronema latifolium leaves in neurodegeneration via in vitro, GC–MS and in silico studies

Probing the multitargeting potential of n-hexane fraction of Gongronema latifolium leaves in neurodegeneration via in vitro, GC–MS and in silico studies

Abstract Background Neurodegenerative disorders (NDDs) are associated with increased activities of brain acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and monoamine oxidase (MAO) as well as Aβ-amyloid (Aβ) neurotoxicity; therefore, they offer a therapeutic option for the treatment of NDD...

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Bibliographic Details
Main Authors: Gideon A. Gyebi, Joseph C. Ejoh, Oludare M. Ogunyemi, Auza Moses Ibrahim, Ibrahim M. Ibrahim, Saheed O. Afolabi, Gabriel O. Anyanwu, Rotimi J. Ojo, Olalekan B. Ogunro, Badriyah S. Alotaibi, Gaber El-Saber Batiha
Format: Article
Language:English
Published: SpringerOpen 2023-10-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Gongronema latifolium
Acetylcholinesterase
Butyrylcholinesterase
Monoamine oxidase
Amyloid-β (Aβ) fibrils
Ensembled-molecular docking, dihydroactinidiolide
Online Access:https://doi.org/10.1186/s43094-023-00536-7

Internet

https://doi.org/10.1186/s43094-023-00536-7

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