Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats

Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats

ABSTRACTObjectives To observe the protective effects of dexmedetomidine (Dex) postconditioning on myocardial ischemia/reperfusion injury (IRI) and to explore its potential molecular mechanisms.Methods One-hundred forty-seven male Sprague-Dawley rats were randomly divided into five groups receiving t...

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Bibliographic Details
Main Authors: Bin Hu, Tian Tian, Xin-Tao Li, Pei-Pei Hao, Wei-Chao Liu, Ying-Gui Chen, Tian-Yu Jiang, Pei-Shan Chen, Yi Cheng, Fu-Shan Xue
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Redox Report
Subjects:
Dexmedetomidine
myocardial ischemia/reperfusion injury
oxidative stress
apoptosis
Nrf2/Sirt3/SOD2 signaling pathway
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2022.2158526

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https://www.tandfonline.com/doi/10.1080/13510002.2022.2158526

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