CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons in the brain and spinal cord. Accumulating evidence suggests that ALS is not solely a neuronal cell- or brain tissue-autonomous disease and...

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Bibliographic Details
Main Authors: Shir Zaccai, Anna Nemirovsky, Livnat Lerner, Leenor Alfahel, Ekaterina Eremenko, Adrian Israelson, Alon Monsonego
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
Amyotrophic lateral sclerosis
SOD1 mice
Neuroinflammation
CD4 T cells
Microglia
Antigen presentation
Online Access:https://doi.org/10.1186/s12974-023-03007-1

Internet

https://doi.org/10.1186/s12974-023-03007-1

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