The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

Abstract Background Giant Cell Tumour of Bone (GCT) is a locally aggressive primary bone tumour that usually occurs at the epiphyses of the long bones of the appendicular skeleton with a tendency to recurrence. Recurrent somatic H3F3A mutations have been described in 92% of GCT cases. GCTs involving...

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Bibliographic Details
Main Authors: Federica Scotto di Carlo, Giuseppina Divisato, Maurizio Iacoangeli, Teresa Esposito, Fernando Gianfrancesco
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Giant cell tumour
Clivus
H3F3A gene
Diagnostic algorithm
Differential diagnosis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4291-z

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http://link.springer.com/article/10.1186/s12885-018-4291-z

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