Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation

Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation

Regulatory T cells (Tregs) are instrumental in maintaining immune tolerance and preventing destructive autoimmunity, but how heterogeneous Treg populations are established remains largely unknown. Here, we show that Zfp335 deletion in Tregs failed to differentiate into effector Tregs (eTregs) and lo...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Xin Wang, Lina Sun, Biao Yang, Wenhua Li, Cangang Zhang, Xiaofeng Yang, Yae Sun, Xiaonan Shen, Yang Gao, Bomiao Ju, Yafeng Gao, Dan Liu, Jiapeng Song, Xiaoxuan Jia, Yanhong Su, Anjun Jiao, Haiyan Liu, Lianjun Zhang, Lan He, Lei Lei, WanJun Chen, Baojun Zhang
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: American Society for Clinical Investigation 2023-10-01
Sraith:The Journal of Clinical Investigation
Ábhair:
Autoimmunity
Immunology
Rochtain ar líne:https://doi.org/10.1172/JCI166628

Ar líne

https://doi.org/10.1172/JCI166628

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