Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival

Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival

Glioblastoma multiforme is a challenging disease with limited treatment options and poor survival. Glioblastoma tumours are characterised by hypoxia that activates the hypoxia inducible factor (HIF) pathway and controls a myriad of genes that drive cancer progression. HIF transcription factors are r...

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Bibliographic Details
Main Authors: Eleanor R. Burgess, Rebekah L. I. Crake, Elisabeth Phillips, Helen R. Morrin, Janice A. Royds, Tania L. Slatter, George A. R. Wiggins, Margreet C. M. Vissers, Bridget A. Robinson, Gabi U. Dachs
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
glioma
HIF-1
VEGF
vitamin C
glioblastoma multiforme
2-oxoglutarate dependent dioxygenases
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.829524/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.829524/full

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