Structure-guided product determination of the bacterial type II diterpene synthase Tpn2

Crystal structure elucidation of terpene synthases plays an important role to understand the sequence-structure-function relationships of this enzyme class. Here, the authors determine the crystal structure of bacterial terpene synthase Tpn2, probe the catalytic mechanism by structure-guided mutatio...

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Bibliographic Details
Main Authors: Emma A. Stowell, Michelle A. Ehrenberger, Ya-Lin Lin, Chin-Yuan Chang, Jeffrey D. Rudolf
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00765-6