AVA-NP-695 Selectively Inhibits ENPP1 to Activate STING Pathway and Abrogate Tumor Metastasis in 4T1 Breast Cancer Syngeneic Mouse Model

AVA-NP-695 Selectively Inhibits ENPP1 to Activate STING Pathway and Abrogate Tumor Metastasis in 4T1 Breast Cancer Syngeneic Mouse Model

Cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor that synthesizes cyclic guanosine monophosphate–adenosine monophosphate (2′3′-cGAMP) from ATP and GTP. 2′3′-cGAMP activates the stimulator of interferon genes (STING) pathway, resulting in the production of interferons and pro-inflammatory c...

Full description

Bibliographic Details
Main Authors: Avijit Goswami, Barnali Deb, Sandeep Goyal, Abhishek Gosavi, Mukund Mali, Ashwita M. Martis, Princy Khurana, Mukesh Gangar, Digambar Raykar, Ankita Mohanty, Aditya Kulkarni
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
cancer immunotherapy
ENPP1 inhibitor
STING
2′3′-cGAMP
EMT
4T1 syngeneic model
Online Access:https://www.mdpi.com/1420-3049/27/19/6721

Internet

https://www.mdpi.com/1420-3049/27/19/6721

Similar Items