In Vitro Anticancer Activity of Novel Ciprofloxacin Mannich Base in Lung Adenocarcinoma and High-Grade Serous Ovarian Cancer Cell Lines via Attenuating MAPK Signaling Pathway

In Vitro Anticancer Activity of Novel Ciprofloxacin Mannich Base in Lung Adenocarcinoma and High-Grade Serous Ovarian Cancer Cell Lines via Attenuating MAPK Signaling Pathway

Novel drugs are desperately needed in order to combat a significant challenge due to chemo-therapeutic resistance and bad prognosis. This research aimed to assess the anticancer activity of a newly synthesized ciprofloxacin Mannich base (CMB) on ovarian cancer (OVCAR-3) and lung cancer (A-549) cell...

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Bibliographic Details
Main Authors: Michael A. Fawzy, Rania H. Abu-baih, Gamal El-Din A. Abuo-Rahma, Islam M. Abdel-Rahman, Azza A. K. El-Sheikh, Maiiada H. Nazmy
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
ciprofloxacin
drug repositioning
cancer
apoptosis
cell cycle
MAPK pathway
Online Access:https://www.mdpi.com/1420-3049/28/3/1137

Internet

https://www.mdpi.com/1420-3049/28/3/1137

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