Translation factor accelerating peptide bond formation on the ribosome: EF-P and eIF5A as entropic catalysts and a potential drug targets

Translation factor accelerating peptide bond formation on the ribosome: EF-P and eIF5A as entropic catalysts and a potential drug targets

Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary translation factors that facilitate peptide bond formation when several sequential proline (Pro) residues are incorporated into the nascent chain. EF-P and eIF5A bind to the exit (E) site of the ribosome and contribute to favo...

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Bibliographic Details
Main Authors: Vitalii Mudryi, Frank Peske, Marina Rodnina
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:BBA Advances
Subjects:
Proline
Elongation factor P
Posttranslational modification
Ribosome
EarP
Activation entropy
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160323000030

Internet

http://www.sciencedirect.com/science/article/pii/S2667160323000030

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