TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling
TNF-related apoptosis-inducing ligand (TRAIL or Apo2 or TNFSF10) belongs to the TNF superfamily. When bound to its agonistic receptors, TRAIL can induce apoptosis in tumour cells, while sparing healthy cells. Over the last three decades, this tumour selectivity has prompted many studies aiming at ev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/6/521 |
| _version_ | 1827306723324461056 |
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| author | Abderrahmane Guerrache Olivier Micheau |
| author_facet | Abderrahmane Guerrache Olivier Micheau |
| author_sort | Abderrahmane Guerrache |
| collection | DOAJ |
| description | TNF-related apoptosis-inducing ligand (TRAIL or Apo2 or TNFSF10) belongs to the TNF superfamily. When bound to its agonistic receptors, TRAIL can induce apoptosis in tumour cells, while sparing healthy cells. Over the last three decades, this tumour selectivity has prompted many studies aiming at evaluating the anti-tumoral potential of TRAIL or its derivatives. Although most of these attempts have failed, so far, novel formulations are still being evaluated. However, emerging evidence indicates that TRAIL can also trigger a non-canonical signal transduction pathway that is likely to be detrimental for its use in oncology. Likewise, an increasing number of studies suggest that in some circumstances TRAIL can induce, via Death receptor 5 (DR5), tumour cell motility, potentially leading to and contributing to tumour metastasis. While the pro-apoptotic signal transduction machinery of TRAIL is well known from a mechanistic point of view, that of the non-canonical pathway is less understood. In this study, we the current state of knowledge of TRAIL non-canonical signalling. |
| first_indexed | 2024-04-24T18:27:27Z |
| format | Article |
| id | doaj.art-f59ce7dcad8949dbb6d29369543004bd |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-04-24T18:27:27Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f59ce7dcad8949dbb6d29369543004bd2024-03-27T13:30:39ZengMDPI AGCells2073-44092024-03-0113652110.3390/cells13060521TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic SignallingAbderrahmane Guerrache0Olivier Micheau1Université de Bourgogne, 21000 Dijon, FranceUniversité de Bourgogne, 21000 Dijon, FranceTNF-related apoptosis-inducing ligand (TRAIL or Apo2 or TNFSF10) belongs to the TNF superfamily. When bound to its agonistic receptors, TRAIL can induce apoptosis in tumour cells, while sparing healthy cells. Over the last three decades, this tumour selectivity has prompted many studies aiming at evaluating the anti-tumoral potential of TRAIL or its derivatives. Although most of these attempts have failed, so far, novel formulations are still being evaluated. However, emerging evidence indicates that TRAIL can also trigger a non-canonical signal transduction pathway that is likely to be detrimental for its use in oncology. Likewise, an increasing number of studies suggest that in some circumstances TRAIL can induce, via Death receptor 5 (DR5), tumour cell motility, potentially leading to and contributing to tumour metastasis. While the pro-apoptotic signal transduction machinery of TRAIL is well known from a mechanistic point of view, that of the non-canonical pathway is less understood. In this study, we the current state of knowledge of TRAIL non-canonical signalling.https://www.mdpi.com/2073-4409/13/6/521apoptosismetastasismigrationEMTcancerTNF |
| spellingShingle | Abderrahmane Guerrache Olivier Micheau TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling Cells apoptosis metastasis migration EMT cancer TNF |
| title | TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling |
| title_full | TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling |
| title_fullStr | TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling |
| title_full_unstemmed | TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling |
| title_short | TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling |
| title_sort | tnf related apoptosis inducing ligand non apoptotic signalling |
| topic | apoptosis metastasis migration EMT cancer TNF |
| url | https://www.mdpi.com/2073-4409/13/6/521 |
| work_keys_str_mv | AT abderrahmaneguerrache tnfrelatedapoptosisinducingligandnonapoptoticsignalling AT oliviermicheau tnfrelatedapoptosisinducingligandnonapoptoticsignalling |