Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development

Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development

Background: Pseudohypoxic tumors activate pro-oncogenic pathways typically associated with severe hypoxia even when sufficient oxygen is present, leading to highly aggressive tumors. Prime examples are pseudohypoxic pheochromocytomas and paragangliomas (p-PPGLs), neuroendendocrine tumors currently l...

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Bibliographic Details
Main Authors: Hermine Mohr, Simone Ballke, Nicole Bechmann, Sebastian Gulde, Jaber Malekzadeh-Najafabadi, Mirko Peitzsch, Vasilis Ntziachristos, Katja Steiger, Tobias Wiedemann, Natalia S. Pellegata
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
animal model
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endogenous pheochromocytoma
pseudohypoxia
PPGLs
oncometabolites
Online Access:https://www.mdpi.com/2072-6694/13/1/126

Internet

https://www.mdpi.com/2072-6694/13/1/126

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