Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease

Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease

Abstract Background Identifying blood-based signatures of brain health and preclinical pathology may offer insights into early disease mechanisms and highlight avenues for intervention. Here, we systematically profiled associations between blood metabolites and whole-brain volume, hippocampal volume...

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Bibliographic Details
Main Authors: Rebecca E. Green, Jodie Lord, Marzia A. Scelsi, Jin Xu, Andrew Wong, Sarah Naomi-James, Alex Handy, Lachlan Gilchrist, Dylan M. Williams, Thomas D. Parker, Christopher A. Lane, Ian B. Malone, David M. Cash, Carole H. Sudre, William Coath, David L. Thomas, Sarah Keuss, Richard Dobson, Cristina Legido-Quigley, Nick C. Fox, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, The Insight 46 study team
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Metabolites
Dementia
Brain imaging
Ageing
Polygenic scores
Birth cohort
Online Access:https://doi.org/10.1186/s13195-023-01184-y

Internet

https://doi.org/10.1186/s13195-023-01184-y

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