Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel.

Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel.

Inherited human long-QT2 syndrome (LQTS) results from mutations in the gene encoding the HERG channel. Several LQT2-associated mutations have been mapped to the amino terminal cytoplasmic Per-Arnt-Sim (PAS) domain of the HERG1a channel subunit. Here we have characterized the trafficking properties o...

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Bibliographic Details
Main Authors: Carol A Harley, Catarina S H Jesus, Ricardo Carvalho, Rui M M Brito, João H Morais-Cabral
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3292575?pdf=render

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http://europepmc.org/articles/PMC3292575?pdf=render

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