Sequential Biotherapy Targeting IL-5 and IL-4/13 in Patients with Eosinophilic Asthma with Sinusitis and Otitis Media

Sequential Biotherapy Targeting IL-5 and IL-4/13 in Patients with Eosinophilic Asthma with Sinusitis and Otitis Media

Type 2 (T2) inflammation plays an important role in the pathogenesis of allergic diseases such as asthma, eosinophilic chronic rhinosinusitis (ECRS), or eosinophilic otitis media (EOM). Currently, in severe asthma with the T2 phenotype, biologics targeting mediators of T2 inflammation dramatically i...

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Bibliographic Details
Main Authors: Ayumi Chikumoto, Keiji Oishi, Kazuki Hamada, Tsunahiko Hirano, Tomoyuki Kakugawa, Keiko Kanesada, Kazuto Matsunaga
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomolecules
Subjects:
sequential biotherapy
anti-IL-5 receptor antibody
anti-IL-4/13 receptor monoclonal antibody
multiple Type 2 inflammatory pathways
eosinophil sinusitis
eosinophilia otitis media
Online Access:https://www.mdpi.com/2218-273X/12/4/522

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https://www.mdpi.com/2218-273X/12/4/522

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