Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling

Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling

Abstract Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A combination of drugs is required to effectively treat this disease. Computational models are critical for combination therapy discovery due to the tens of thousands of...

Full description

Bibliographic Details
Main Authors: Mehdi Mirzaie, Elham Gholizadeh, Juho J. Miettinen, Filipp Ianevski, Tanja Ruokoranta, Jani Saarela, Mikko Manninen, Susanna Miettinen, Caroline A. Heckman, Mohieddin Jafari
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-024-00510-9

Internet

https://doi.org/10.1038/s41389-024-00510-9

Similar Items