HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal

HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal

Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well defined. HSV-2 recurrences result in an influx of activated CD4+ T cells to sites of viral replication and an increase in activated CD4+ T ce...

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Bibliographic Details
Main Authors: Carl A. Pierce, Lip Nam Loh, Holly R. Steach, Natalia Cheshenko, Paula Preston-Hurlburt, Fengrui Zhang, Stephanie Stransky, Leah Kravets, Simone Sidoli, William Philbrick, Michel Nassar, Smita Krishnaswamy, Kevan C. Herold, Betsy C. Herold
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-06-01
Series:The Journal of Clinical Investigation
Subjects:
AIDS/HIV
Virology
Online Access:https://doi.org/10.1172/JCI164317

Internet

https://doi.org/10.1172/JCI164317

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