Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

Malvezzi et al. discuss the impact of BRD4 phosphorylation on the formation of dimers and identify the key residues necessary for this dimerization. They also discuss the differential role of monovalent and bivalents bromodomain inhibitors regarding the interaction with these dimers and suggest a ne...

Full description

Bibliographic Details
Main Authors: Francesca Malvezzi, Christopher J. Stubbs, Thomas A. Jowitt, Ian L. Dale, Xieyang Guo, Jon P. DeGnore, Gianluca Degliesposti, J. Mark Skehel, Andrew J. Bannister, Mark S. McAlister
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02750-6