A specific folate activates serotonergic neurons to control C. elegans behavior

A specific folate activates serotonergic neurons to control C. elegans behavior

Abstract Folates are B-group vitamins that function in one-carbon metabolism. Here we show that a specific folate can activate serotonergic neurons in C. elegans to modulate behavior through a pathway that requires the folate receptor FOLR-1 and the GON-2 calcium channel. FOLR-1 and GON-2 physically...

Full description

Bibliographic Details
Main Authors: Ria S. Peesapati, Brianna L. Austin-Byler, Fathima Zahra Nawaz, Jonathan B. Stevenson, Stanelle A. Mais, Rabia N. Kaya, Michael G. Hassan, Nabraj Khanal, Alexandra C. Wells, Deena Ghiai, Anish K. Garikapati, Jacob Selhub, Edward T. Kipreos
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52738-z

Internet

https://doi.org/10.1038/s41467-024-52738-z

Similar Items