Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

Abstract Background Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are costored in WPBs are subject to alternative trafficking rou...

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Bibliographic Details
Main Authors: Maaike Schillemans, Marije Kat, Jurjen Westeneng, Anastasia Gangaev, Menno Hofman, Benjamin Nota, Floris P. J. van Alphen, Martin de Boer, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
endothelial cells
gene knockout techniques
protein transport
secretory vesicles
von Willebrand factor
Online Access:https://doi.org/10.1002/rth2.12242

Internet

https://doi.org/10.1002/rth2.12242

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