Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation

Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation

Humoral alloreactivity has been recognized as a common cause of kidney transplant dysfunction. B-cell activation, differentiation, and antibody production are dependent on IL-21+CXCR5+follicular T-helper (Tfh) cells. Here, we studied whether belatacept, an inhibitor of the costimulatory CD28-CD80/86...

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Bibliographic Details
Main Authors: Gretchen N. de Graav, Dennis A. Hesselink, Marjolein Dieterich, Rens Kraaijeveld, Wenda Verschoor, Dave L. Roelen, Nicolle H. R. Litjens, Anita S. Chong, Willem Weimar, Carla C. Baan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
belatacept
costimulatory blockade
follicular T-helper cells
immunoglobulins
plasmablasts
tacrolimus
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00641/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00641/full

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