Inward Rectifier K+ Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM‐IbΔC‐X

Inward Rectifier K+ Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM‐IbΔC‐X

BACKGROUND Transgenic mice (TG) with heart‐directed overexpresion of the isoform of the transcription factor cyclic adenosine monophosphate response element modulator (CREM), CREM‐IbΔC‐X, display spontaneous atrial fibrillation (AF) and action potential prolongation. The remodeling of the underlying...

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Bibliographic Details
Main Authors: Florentina Pluteanu, Matthias D. Seidl, Sabine Hamer, Beatrix Scholz, Frank U. Müller
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atrial fibrillation
electrical remodeling
inward rectifiers
K+ channel
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.016144

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https://www.ahajournals.org/doi/10.1161/JAHA.119.016144

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