Longitudinal PET studies of mGluR5 in FXS using an FMR1 knockout mouse model

Longitudinal PET studies of mGluR5 in FXS using an FMR1 knockout mouse model

Fragile X syndrome (FXS) is a monogenic disorder characterized by intellectual disability and behavioral challenges. It is caused by aberrant methylation of the fragile X mental retardation 1 (FMR1) gene. Given the failure of clinical trials in FXS and growing evidence of a role of metabotropic glut...

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Bibliographic Details
Main Authors: Afshar Sepideh, Lule Sevda, Yuan Gengyang, Qu Xiying, Pan Chuzhi, Whalen Michael, Brownell Anna-Liisa, Mody Maria
Format: Article
Language:English
Published: De Gruyter 2022-04-01
Series:Translational Neuroscience
Subjects:
fxs
positron emission tomography
[18f]fpeb
metabotropic glutamate receptor 5
mouse model
Online Access:https://doi.org/10.1515/tnsci-2022-0217

Internet

https://doi.org/10.1515/tnsci-2022-0217

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