Longitudinal PET studies of mGluR5 in FXS using an FMR1 knockout mouse model
Fragile X syndrome (FXS) is a monogenic disorder characterized by intellectual disability and behavioral challenges. It is caused by aberrant methylation of the fragile X mental retardation 1 (FMR1) gene. Given the failure of clinical trials in FXS and growing evidence of a role of metabotropic glut...
Main Authors: | Afshar Sepideh, Lule Sevda, Yuan Gengyang, Qu Xiying, Pan Chuzhi, Whalen Michael, Brownell Anna-Liisa, Mody Maria |
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Format: | Article |
Language: | English |
Published: |
De Gruyter
2022-04-01
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Series: | Translational Neuroscience |
Subjects: | |
Online Access: | https://doi.org/10.1515/tnsci-2022-0217 |
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