Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9

Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9

Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency and immunogenicity of plant-derived proteins. Succe...

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Bibliographic Details
Main Authors: Kathrin Göritzer, Melanie Grandits, Clemens Grünwald-Gruber, Rudolf Figl, Sébastien Mercx, Catherine Navarre, Julian K-C. Ma, Audrey Y-H. Teh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Plant Science
Subjects:
N-glycosylation
glycoengineering
molecular pharming
recombinant protein production
CRISPR/Cas9
genome editing
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2022.1003065/full

Internet

https://www.frontiersin.org/articles/10.3389/fpls.2022.1003065/full

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