Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis

T cells express specific T cell receptors (TCR) to recognise antigens and initiate adaptive immune responses. Here the authors show, in a mouse model of autoimmune encephalomyelitis, that memory-like CD4 T cells expressing unrelated TCR can also infiltrate the spinal cord and contribute to autoimmun...

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Bibliographic Details
Main Authors: Hong-Gyun Lee, Jae-Ung Lee, Do-Hyun Kim, Sangho Lim, Insoo Kang, Je-Min Choi
Format: Article
Language:English
Published: Nature Portfolio 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08482-w