Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification

Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification

Abstract There is strong evidence that obesity is a risk factor for poor semen quality. However, the effects of multigenerational paternal obesity on the susceptibility to cadmium (a reproductive toxicant)-induced spermatogenesis disorders in offspring remain unknown. Here, we show that, in mice, sp...

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Bibliographic Details
Main Authors: Yong-Wei Xiong, Hua-Long Zhu, Jin Zhang, Hao Geng, Lu-Lu Tan, Xin-Mei Zheng, Hao Li, Long-Long Fan, Xin-Run Wang, Xu-Dong Zhang, Kai-Wen Wang, Wei Chang, Yu-Feng Zhang, Zhi Yuan, Zong-Liu Duan, Yun-Xia Cao, Xiao-Jin He, De-Xiang Xu, Hua Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45675-4

Internet

https://doi.org/10.1038/s41467-024-45675-4

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