A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta

There is growing recognition regarding the role of intracellular amyloid beta (Aβ) in the Alzheimer’s disease process, which has been linked with aberrant signaling and the disruption of protein degradation mechanisms. Most notably, intraneuronal Aβ likely underlies the o...

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Bibliographic Details
Main Authors: Silvia Hilt, Robin Altman, Tamás Kálai, Izumi Maezawa, Qizhi Gong, Sebastian Wachsmann-Hogiu, Lee-Way Jin, John C. Voss
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
amyloid beta
Alzheimer’s disease
bifunctional drug
Aβ oligomer
oxidative stress
intraneuronal Aβ
intracellular Aβ
nitroxide antioxidant
spin label
Online Access:http://www.mdpi.com/1420-3049/23/8/2010

Internet

http://www.mdpi.com/1420-3049/23/8/2010

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