The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis

The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis

Infiltrating CD4 and CD8 T cells have been shown to worsen inflammatory liver damage in non-alcoholic steatohepatitis (NASH). Inhibitory T cell receptors such as the programmed cell death protein 1 (PD1) and the natural killer cell receptor 2B4 regulate the activity of CD4 and CD8 T cells and theref...

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Detalhes bibliográficos
Principais autores: Cordula Hansel, Stephanie Erschfeld, Maike Baues, Twan Lammers, Ralf Weiskirchen, Christian Trautwein, Daniela C. Kroy, Hannah K. Drescher
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2019-03-01
coleção:Frontiers in Pharmacology
Assuntos:
Western diet
inhibitory T cell receptors
non-alcoholic steatohepatitis
NASH
liver
programmed cell death protein 1
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2019.00244/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00244/full

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