Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

IntroductionThe neuron-specific K-Cl cotransporter KCC2 maintains low intracellular chloride levels, which are crucial for fast GABAergic and glycinergic neurotransmission. KCC2 also plays a pivotal role in the development of excitatory glutamatergic neurotransmission by promoting dendritic spine ma...

Полное описание

Библиографические подробности
Главные авторы: Pavel Uvarov, Satoshi Fudo, Cem Karakus, Andrey Golubtsov, Federico Rotondo, Tatiana Sukhanova, Shetal Soni, Coralie Di Scala, Tommi Kajander, Claudio Rivera, Anastasia Ludwig
Формат: Статья
Язык:English
Опубликовано: Frontiers Media S.A. 2025-01-01
Серии:Frontiers in Molecular Neuroscience
Предметы:
KCC2
SLC12A5
GABA
chloride homeostasis
Mu transposon mutagenesis
KCC2-CTD mutations
Online-ссылка:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1505722/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2024.1505722/full

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