Urine Biomarkers of Risk in the Molecular Etiology of Breast Cancer

Endogenous estrogens can be bio-activated to endogenous carcinogens via formation of estrogen quinones. Estrogen-3,4-quinones react with DNA to form mutagenic depurinating estrogen-DNA adducts. The carcinogenicity of endogenous estrogens is related to unbalanced estrogen metabolism leading to excess...

Full description

Bibliographic Details
Main Authors: Nilesh W. Gaikwad, Li Yang, Sandhya Pruthi, James N. Ingle, Nicole Sandhu, Eleanor G. Rogan, Ercole L. Cavalieri
Format: Article
Language:English
Published: SAGE Publishing 2009-01-01
Series:Breast Cancer: Basic and Clinical Research
Subjects:
Online Access:http://www.la-press.com/urine-biomarkers-of-risk-in-the-molecular-etiology-of-breast-cancer-a1258