The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor.

The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor.

Machupo virus (MACV), a New World arenavirus, is the etiological agent of Bolivian hemorrhagic fever (BHF). Junin virus (JUNV), a close relative, causes Argentine hemorrhagic fever (AHF). Previously, we reported that a recombinant, chimeric MACV (rMACV/Cd#1-GPC) expressing glycoprotein from the Cand...

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Bibliographic Details
Main Authors: Takaaki Koma, Cheng Huang, Judith F Aronson, Aida G Walker, Milagros Miller, Jeanon N Smith, Michael Patterson, Slobodan Paessler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5006991?pdf=render

Internet

http://europepmc.org/articles/PMC5006991?pdf=render

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