Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer

Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer

Abstract Pazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic activities against various human cancers. However, its clinical utility is limited by substantial side effects and therapeutic resistance. We developed a nanoplatform capable of delivering PAZ for en...

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Bibliographic Details
Main Authors: Zhijie Xu, Zhiyang Zhou, Xiaoxin Yang, Abhimanyu Thakur, Ning Han, Hai-Tao Li, Liu-Gen Li, Jun Hu, Tong-fei Li, Yuanliang Yan
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Journal of Nanobiotechnology
Subjects:
Pazopanib
Metal-organic framework
Immune microenvironment
M2-like macrophages
Breast cancer
Online Access:https://doi.org/10.1186/s12951-024-02694-z

Internet

https://doi.org/10.1186/s12951-024-02694-z

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