Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction

Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction

The IFITMs inhibit influenza A virus (IAV) replication in vitro and in vivo. Here, we establish that the antimycotic heptaen, amphotericin B (AmphoB), prevents IFITM3-mediated restriction of IAV, thereby increasing viral replication. Consistent with its neutralization of IFITM3, a clinical preparati...

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Bibliographic Details
Main Authors: Tsai-Yu Lin, Christopher R. Chin, Aaron R. Everitt, Simon Clare, Jill M. Perreira, George Savidis, Aaron M. Aker, Sinu P. John, David Sarlah, Erick M. Carreira, Stephen J. Elledge, Paul Kellam, Abraham L. Brass
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713006177

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http://www.sciencedirect.com/science/article/pii/S2211124713006177

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