An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

<p>Abstract</p> <p>We have developed a highly effective method for <it>in vivo </it>gene silencing in the spinal cord and dorsal root ganglia (DRG) by a cationic lipid facilitated delivery of synthetic, small interfering RNA (siRNA). A siRNA to the delta opioid receptor...

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Bibliographic Details
Main Authors: Porreca Frank, Shuster Sam J, Huang Yuan-Yuan, Ma Shou-Wu, Zhang Dong-Qin, Luo Miaw-Chyi, Lai Josephine
Format: Article
Language:English
Published: SAGE Publishing 2005-09-01
Series:Molecular Pain
Subjects:
rat
antinociception
sensory neurons
spinal cord
knockdown
RNA interference
Online Access:http://www.molecularpain.com/content/1/1/29

Internet

http://www.molecularpain.com/content/1/1/29

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