Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

Abstract Background The dysregulation of histone deacetylase (HDAC) protein expression or its enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme activity induced by deoxycorticosterone acetate (DOCA) hypertension was attenuated by sodium valproate, a pan-HDAC inhi...

Full description

Bibliographic Details
Main Authors: Hae Jin Kee, Yuhee Ryu, Young Mi Seok, Sin Young Choi, Simei Sun, Gwi Ran Kim, Myung Ho Jeong
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Clinical Hypertension
Subjects:
PCI34051
Hypertension
Arterial remodeling
Vascular relaxation
Inflammation
Online Access:http://link.springer.com/article/10.1186/s40885-019-0118-8

Internet

http://link.springer.com/article/10.1186/s40885-019-0118-8

Similar Items