Combination of Docking-Based and Pharmacophore-Based Virtual Screening Identifies Novel Agonists That Target the Urotensin Receptor

Combination of Docking-Based and Pharmacophore-Based Virtual Screening Identifies Novel Agonists That Target the Urotensin Receptor

The urotensin receptor (UT receptor), a G-protein-coupled receptor mediating urotensin-II and urotensin-II-related peptide signaling in the urotensinergic system, has multiple pharmacological activities. However, there is no drug targeting the UT receptor currently in clinical use, and the discovery...

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Bibliographic Details
Main Authors: Na Li, Lin Yin, Xi Chen, Jiamin Shang, Meidai Liang, Li Gao, Guifen Qiang, Jie Xia, Guanhua Du, Xiuying Yang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
urotensin receptor
urotensin-II
docking-based virtual screening
pharmacophore-based virtual screening
drug screening
Online Access:https://www.mdpi.com/1420-3049/27/24/8692

Internet

https://www.mdpi.com/1420-3049/27/24/8692

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