Protein kinase B/AKT phosphorylates hypoxia-inducible factor-3α1 in response to insulin, promoting cell growth and migration

Protein kinase B/AKT phosphorylates hypoxia-inducible factor-3α1 in response to insulin, promoting cell growth and migration

Hypoxia-inducible factors (HIFs) are best known for their roles in the adaptation to low oxygen environments. Besides hypoxia, HIF-1/2 α-subunits are also regulated by various non-hypoxic stimuli including insulin which can act via the PI3K/protein kinase B (PKB) signaling pathway. However, with res...

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Bibliographic Details
Main Authors: Tran Vinh Hong Nguyen, Ulrich Bergmann, Thomas Kietzmann, Daniela Mennerich
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HIF-3α
insulin
PKB/AKT
hypoxia
phosphorylation
cell migration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1250000/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1250000/full

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