Proline and Proline Analogues Improve Development of Mouse Preimplantation Embryos by Protecting Them against Oxidative Stress

Proline and Proline Analogues Improve Development of Mouse Preimplantation Embryos by Protecting Them against Oxidative Stress

The culture of embryos in the non-essential amino acid L-proline (Pro) or its analogues pipecolic acid (PA) and L-4-thiazolidine carboxylic acid (L4T) improves embryo development, increasing the percentage that develop to the blastocyst stage and hatch. Staining of 2-cell and 4-cell embryos with tet...

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Bibliographic Details
Main Authors: Madeleine L. M. Hardy, Dheerja Lakhiani, Michael B. Morris, Margot L. Day
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
mitochondrial activity
oxidative stress
pipecolic acid
pre-implantation embryo development
proline
reactive oxygen species
Online Access:https://www.mdpi.com/2073-4409/12/22/2640

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