Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments
Calvaresi et al. use hydrogen-deuterium exchange coupled to mass spectrometry to compare the conformational dynamics of the human heat shock protein Hsp70 when free and when associated with liposomes composed of common lysosomal lipids. They also investigate the conformational changes occuring in Hs...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02892-7 |