Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function

Neutrophil extracellular traps contribute to lung injury in cystic fibrosis and asthma, but the mechanisms are poorly understood. We sought to understand the impact of human NETs on barrier function in primary human bronchial epithelial and a human airway epithelial cell line. We demonstrate that NE...

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Bibliographic Details
Main Authors: K. M. Hudock, M. S. Collins, M. A. Imbrogno, E. L. Kramer, J. J. Brewington, A. Ziady, N. Zhang, J. Snowball, Y. Xu, B. C. Carey, Y. Horio, S. M. O’Grady, E. J. Kopras, J. Meeker, H. Morgan, A. J. Ostmann, E. Skala, M. E. Siefert, C. L. Na, C. R. Davidson, K. Gollomp, N. Mangalmurti, B. C. Trapnell, J. P. Clancy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
NETs (neutrophil extracellular traps)
alpha-1 antitrypsin (A1AT)
barrier function
bronchial epithelia
E-cadherin (CDH1)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023553/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023553/full

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